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Title 

Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata

Authors 

In Kyoung LeeBong Sik YunGyoon Hee HanD H ChoY H KimIck Dong Yoo

Publisher 

American Chemical Society

Issue Date 

2002

Citation 

Journal of Natural Products, vol. 65, no. 12, pp. 1769-1772

Keywords 

1 formyl 3 (2 hydroxymethyl 4 methoxyphenyl) 6 methoxyl 2 hydro 4 quinazolinone1 formyl 3 (2 hydroxymethyl 4 methoxyphenyl) 6 methoxyl 2,4 dihydroquinazolineglutamic acidn methyl dextro aspartic acidplant extractquinazoline derivativeunclassified druganimal cellbrain cellcarbon nuclear magnetic resonance

Abstract 

In an effort to identify neuroprotective compounds against excitatory neurotoxins from edible and medicinal mushrooms, dictyoquinazols A (1), B (2), and C (3) have been isolated from the methanolic extract of the mushroom Dictyophora indusiata. On the basis of NMR studies, their structures have been assigned as unique quinazoline compounds, which are very rare in nature. 2 and 3 existed as mixtures of rotamers (2a, 2b and 3a, 3b) inseparable by HPLC because of fast interconversion. The E/Z isomers of these compounds were assigned by comparison of 1H NMR, 13C NMR, and NOESY spectra and by 3JC.H coupling constants. Dictyoquinazols protected primary cultured mouse cortical neurons from glutamate- and NMDA-induced excitotoxicities in a dose-dependent manner.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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