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Title 

Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-κB pathway in lipopolysaccharide-stimulated macrophage

Authors 

Sung Yeon ChoSang Joon ParkMyung Ja KwonTae Sook JeongSong Hae BokW Y ChoiW I JeongS Y RyuS H DoC S LeeJ C SongK S Jeong

Publisher 

Springer Verlag (Germany)

Issue Date 

2003

Citation 

Molecular and Cellular Biochemistry, vol. 243, no. 1, pp. 153-160

Keywords 

anti-inflammationLPSMAP-kinasesNF-κBquercetinantiinflammatory agentbeta actinI kappa B betaimmunoglobulin enhancer binding proteininterleukin 1beta

Abstract 

Quercetin is a flavonoid molecule ubiquitous in nature and functions as an anti-oxidant and anti-inflammatory agent with little toxicity in vivo and in vitro. Dose- and time-dependent effect of quercetin has been investigated on proinflammatory cytokine expression and NO production, focusing on its effects on the MAP kinases and the NF-κB signal transduction pathways in LPS-stimulated RAW 264.7 cells by using RT-PCR and immunoblotting. Quercetin strongly reduced activation of phosphorylated ERK kinase and p38 MAP kinase but not JNK MAP kinase by LPS treatment. In addition, quercetin treatment inhibited NF-κB activation through stabilization of the NF-κB/IκB complex and IκB degradation and proinflammatory cytokines and NO/iNOS expression. Quercetin may exert its anti-inflammatory and immunomodulatory properties in the effect molecules such as proinflammatory cytokines and NO/iNOS by suppressing the activation of ERK and p38 MAP kinase, and NF-κB/IκB signal transduction pathways.

ISSN 

0300-8177

Link 

http://dx.doi.org/10.1023/A:1021624520740

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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