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Title 

Forensic value of 14 novel STRs on the human Y chromosome

Authors 

A J ReddA B AgellonV A KearneyV A ContrerasT KarafetHwa Yong ParkP KnijffJ M ButlerM F Hammer

Publisher 

Elsevier

Issue Date 

2002

Citation 

Forensic Science International, vol. 130, no. 2, pp. 97-111

Keywords 

gene diversityhumansmicrosatelliteshort-tandem-repeat (STR)y-chromosomeY-STRcontrolled studyforensic sciencegene frequencygenetic variability

Abstract 

We identified and characterized 14 novel short-tandem-repeats (STRs) on the Y chromosome and typed them in two samples, a globally diverse panel of 73 cell lines, and 148 individuals from a European-American population. These Y-STRs include eight tetranucleotide repeats (DYS449, DYS453, DYS454, DYS455, DYS456, DYS458, DYS459, and DYS464), five pentanucleotide repeats (DYS446, DYS447, DYS450, DYS452, and DYS463), and one hexanucleotide repeat (DYS448). Sequence data were obtained to designate a repeat number nomenclature. The gene diversities of an additional 22 Y-STRs, including the most commonly used in forensic databases, were directly compared in the cell line DNAs. Six of the 10 most polymorphic markers include the newly identified Y-STRs. Furthermore, these novel Y-STRs greatly improved the resolution of paternal lineages, above the level obtained with commonly used Y-STRs, in the European-American population.

ISSN 

0379-0738

Link 

http://dx.doi.org/10.1016/S0379-0738(02)00347-X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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