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Title 

Antiinvasive, antiangiogenic and antitumour activity of Ephedra sinica extract

Authors 

N H NamChang Woo LeeDong Ho HongHwan Mook KimK H BaeB Z Ahn

Publisher 

Wiley-Blackwell

Issue Date 

2003

Citation 

Phytotherapy Research, vol. 17, no. 1, pp. 70-76

Keywords 

antiangiogenic activityantiinvasive activityantitumour activitycytotoxicityephedra sinicaephedra sinica extractantineoplastic activitydrug activityextractionplant extracts

Abstract 

A water fraction (EW), the remaining water phase from the methanol extract of Ephedra sinica after extraction with ethyl acetate and butanol, has been investigated for its antiangiogenic, antiinvasive and antitumour activities. It was observed that EW, at 30 μg/mL, a non-cytotoxic concentration, inhibited the tube formation induced by human umbilical venous endothelial cells and the invasion of B16F10 melanoma cells through a matrix membrane by more than 90%. At 30 mg/kg/day, the inhibitory activity of EW on the growth of a tumour mass in BDF1 mice inoculated with B16-F10 murine melanoma cells was comparable to that of adriamycin (ADR) administered at 2 mg/kg/day. From these results, it could be postulated that the antitumour activity of the water fraction might be attributed to its antiangiogenic and antiinvasive activities.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.901

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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