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Title 

Inhibitory effects of natural plant extracts on ICAM-1/LFA-1 mediated adhesion of HL-60 cells

 

자생식물 추출물의 세포접착인자 저해활성 검색

Authors 

Oh Eok KwonSeung Woong LeeMi Yeon ChungY H KimMun Chual RhoHyun Sun LeeYoung Kook Kim

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2002

Citation 

Korean Journal of Pharmacognosy, vol. 33, no. 4, pp. 343-351

Keywords 

atherosclerosiscell adhesion moleculesHL-60 cellsICAM-1plant extractsanemone koraiensis extractaster glehni extractcedrela sinensis extractcell adhesion moleculechloranthus japonicus

Abstract 

Atherosclerosis is a progressive disease characterized by the accumulation of lipids and fibrous elements in the arteries. Monocytes/macrophages are involved in many aspects of the development of atherosclerotic plaques. It is known that the intercellular adhesion molecule-1 (ICAM-1) expressed preferentially on endothelial cells of atherosclerotic plaque, promotes local adhesion and transendothelial migration of monocytes, neutrophils, and lymphocytes. Using the human promyelocytic leukemia HL-60 cell line, we investigated the inhibitory effects of methanol extracts of 175 natural plants on ICAM-1/LFA-1 mediated cell adhesion. Eight kinds of methanol extracts of tested plants inhibited PMA-induced homotypic aggregation of HL-60 cells without cytotoxicity at the concentration of 6.25 μg/ml. They were divided two fractions of CHCl3 and H2O to use solvent partition. Among them, CHCl3 extracts (1.0 μg/ml) of Saururus chinensis and Chloranthus japonicus significantly inhibited aggregation of HL-60 cells without cytotoxicity, respectively.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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