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Title 

Effect of Korea red ginseng on cerebral blood flow and superoxide production

Authors 

C S KimJ B ParkK J KimS J ChangSung Woo RyooB H Jeon

Publisher 

Nature Publishing Group

Issue Date 

2002

Citation 

Acta Pharmacologica Sinica, vol. 23, no. 12, pp. 1152-1156

Keywords 

cerebral blood flowKorean red ginsengsuperoxidesvascular endotheliumginseng extractreduced nicotinamide adenine dinucleotide phosphatesuperoxidebrain blood flowbrain blood vesseldrug effect

Abstract 

AIM: To investigate the effects of Korea red ginseng (KRG) on the cerebral perfusion rate in the rats and the generation of superoxide anion in the endothelial cells. METHODS: The cerebral perfusion rate was measured using laser-doppler flowmetry before and after the administration of crude saponin (CS) and saponin-free fraction (SFF) of KRG in the anesthetized rats. The superoxide generation was measured by the method based on lucigenin- enhanced chemiluminescence in the cultured endothelial cells. RESULTS: The relative cerebral perfusion rate (rCBF) was significantly increased by the intraperitoneal injection of CS (100 mg/kg) in the rats, but SFF had no effect on the rCBF. Chronic treatment with CS for 7 d significantly inhibited the decrease of forebrain cerebral blood flow induced by clamping both carotid arteries in the rats. Furthermore, CS (0.1 g/L) significantly suppressed NADPH-induced superoxide generation in the human umbilical vein endothelial cells (P<0.01). CONCLUSION: The present study demonstrated that crude saponin fraction of KRG enhanced cerebral blood flow in rats. Furthermore, crude saponin fraction of KRG abrogated the NADPH-driven superoxide generation in endothelial cells.

ISSN 

1671-4083

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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