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Title 

Lignans with inhibitory activity against NFAT transcription from Schisandra chinensis

Authors 

I S LeeHyeong Kyu LeeN T DatM S LeeJ W KimD S NaY H Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2003

Citation 

Planta Medica, vol. 69, no. 1, pp. 63-64

Keywords 

schisandra chinensis extracttranscription factor NFATdrug activitytranscription regulationlignansNFATC transcription factorsschisandratranscription factorsschisandra chinensis

Abstract 

Seven lignans from Schisandra chinensis were investigated for their inhibitory activity on NFAT transcription. Both gomisin N (IC50: 1.33 ± 0.05 μM) and schisandrol A (IC50: 1.34 ± 0.05 μM) showed higher activity than gomisin E (IC50:4.73 ± 0.09 μM), schisandrin A (IC50: 7.23 ± 0.21 μM), schisandrin C (IC50: 7.54 ± 0.22 μM), benzoylisogomisin O (IC50: 11.06 ± 1.02 μM) and schisandrol B (IC50: 16.37 ± 1.00 μM).

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2003-37024

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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