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Title 

Antitumor activity of flavones isolated from Artemisia argyi

Authors 

Jeong Min SeoHyun Mi KangKwang Hee SonJong Han KimChang Woo LeeHwan Mook KimS I ChangByoung-Mog Kwon

Publisher 

Georg Thieme Verlag

Issue Date 

2003

Citation 

Planta Medica, vol. 69, no. 3, pp. 218-222

Keywords 

angiogenesisartemisia argyicompositaefarnesyl protein transferaseflavones5,6 dihydroxy 7,3',4' trimethoxyflavone5,6,4' trihydroxy 7,3' dimethoxyflavone5,7,3' trihydroxy 6,4',5' trimethoxyflavoneartemisia argyi extractflavone derivative

Abstract 

The flavones 5,6-dihydroxy-7,3′,4′-trimethoxyflavone (1), 5,6,4′-trihydroxy-7,3′-dimethoxyflavone (2), 5-hydroxy-3′,4′,6,7-tetramethoxyflavone, 5,7,3′-trihydroxy-6,4′,5′-trimethoxyflavone, ladanein, and hispidulin were isolated from the methanolic extracts of the aerial parts of Artemisia argyi and structures of the compounds were elucidated on the basis of their spectral data. These flavones inhibited farnesyl protein transferase with IC50 values of 25-200/ μg/mL. Compound 2 inhibited proliferation of a couple of tumor cell lines and also inhibited neovascularization in a chick chorioallantoic membrane assay. Without loss of body weight of nude mice, compounds I and 2 inhibited growth of a colon tumor (SW620) by 44.6% and 14.6%, respectively.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2003-38486

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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