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Title 

Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G(2)/M phase

Authors 

Ha Won JeongDong Cho HanKwang Hee SonMi Young HanJong-Seok LimJ H HaChang Woo LeeHwan Mook KimHyoung-Chin KimByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2003

Citation 

Biochemical Pharmacology, vol. 65, no. 8, pp. 1343-1350

Keywords 

antitumorcell cyclecinnamaldehydecyclincinnamaldehyde derivativeanimal cellcancer cell culturecell adhesioncell assaycell cycle G2 phase

Abstract 

Cinnamaldehydes have been shown to have inhibitory effects on farnesyl protein transferase (FPTase; EC 2.5.1.29) in vitro, angiogenesis, cell-cell adhesion, and tumor cell growth and to be immunomodulators. However, the mechanisms responsible for these effects remain unknown. To elucidate the molecular mechanism of the cinnamaldehyde derivative CB403 for growth inhibition, CB403 was synthesized from 2′-hydroxycinnamaldehyde. CB403-treated cells were weakly adherent to the culture dishes. In addition, CB403 inhibited tumor growth in these cells in a concentration-dependent manner. FACS analysis using human cancer cells treated with this compound showed cell cycle arrest in mitosis, which was correlated with a marked increase in the amount of cyclin B1. Furthermore, CB403 blocked in vivo growth of human colon and breast tumor xenografts without loss of body weight in nude mice. These results support the hypothesis that the cinnamaldehyde derivative CB403 exerts cytostatic properties by inducing mitotic arrest in cancer cells.

ISSN 

0006-2952

Link 

http://dx.doi.org/10.1016/S0006-2952(03)00038-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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