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Title 

Novel 3-arylamino- and 3-cycloalkylamino-5, 6-diphenyl-pyridazines active as ACAT inhibitors

Authors 

L TomaM P GiovannoniC VergelliV D PiazByoung-Mog KwonYoung Kook KimA GelainD Barlocco

Publisher 

Wiley-Blackwell

Issue Date 

2002

Citation 

Archiv der Pharmazie, vol. 335, no. 11, pp. 563-566

Keywords 

5,6-Diphenylpyridazine derivativesACAT inhibitorsAcyl-CoA:cholesterol acyltransferase (ACAT)hypercholesterolemiacholesterol acyltransferase inhibitorenzyme inhibitorspyridazines

Abstract 

A new series of pyridazine derivatives, structurally related to the previously reported ACAT inhibitors 3-(cyclo)alkylamino-5,6-diphenyl-pyridazines, were synthesized and tested for their inhibitory properties. Substitution of the 3-alkylamino chain with a phenylamino group maintains activity. In contrast, the presence of either substituents on the phenylamino group or aliphatic rings having more or less than six carbon atoms lowers it.

ISSN 

0365-6233

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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