상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Inhibitory effects of natural plant extracts on lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase

 

자생식물 추출물의 lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase 저해활성

Authors 

Ha Na YuKyung Hyun ChoD E SokTae Sook Jeong

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2003

Citation 

Korean Journal of Pharmacognosy, vol. 34, no. 1, pp. 100-108

Keywords 

atherosclerosisinflammationLp-PLA2oxidized LDLplant extractslow density lipoprotein cholesteroloxidized low density lipoproteinphospholipase A2phospholipase A2 inhibitorplant extract

Abstract 

The regulation of plasma lipid level, particularly LDL cholesterol, represents the focus of current therapy for atherosclerosis. And Lp-PLA2 is able to hydrolyse oxidized phosphatidylcholine within LDL into lyso-PC and oxidized fatty acids. Lp-PLA2 is a potential biomarker of coronary heart disease and plays an important proinflammatory role in the progression of atherosclerosis. We investigated the inhibitory effects of methanol extracts of 224 natural plants on Lp-PLA2 activity. Seven kinds of methanol extracts of tested plants showed above 50% inhibitory effect with the concentration of 100 μg/ml. The concentrated aqueous suspensions of each methanol extract were partitioned with n-hexane, CHCl3, and EtOAc. Among them, EtOAc extracts of Astilbe chinensis var. davidii (root) and Pourthiaea villosa var. brunnea (leaf) significantly inhibited Lp-PLA2 activity at the same concentration.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)