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Title 

Terreulactones A, B, C, and D : novel acetylcholinesterase inhibitors produced by Aspergillus terreus I. taxonommy, fermentation, isolation and biological activities

Authors 

Kyung Mi ChoWon Gon KimC K LeeIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2003

Citation 

Journal of Antibiotics, vol. 56, no. 4, pp. 344-350

Keywords 

5,5' dithiobis(2 nitrobenzoic acid)acetoneacetylcholinesteraseacetylthiocholinebutyrylthiocholinecholinesterasecholinesterase inhibitorlactone derivativepolyketideterpenoid derivative

Abstract 

In the course of screening for selective inhibitors of acetylcholinesterase from the microbial metabolites, four new meroterpenoid compounds, terreulactones A, B, C and D were isolated from solid state fermentation of Aspergillus terreus Fb000501. They showed potent inhibitory activities against acetylcholinesterase with IC50 values in range of 0.06-0.42 μM. In addition, they exhibited more than 500-3000 times selectivity for acetylcholinesterase compared with butyrylcholinesterase.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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