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Title 

Prevention of macrophage-related inflammatory diseases by allergina

Authors 

Sang Bae HanChang Woo LeeSong Kyu ParkWoon Kee YoonJae Sun MoonKi Hoon LeeHyoung-Chin KimHwan Mook Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2003

Citation 

Archives of Pharmacal Research, vol. 26, no. 4, pp. 312-316

Keywords 

allerginacollagen-induced arthritisdelayed type hypersensitivitygraft-versus-host diseasesantiinflammatory agentmacrophageanti-Inflammatory agentsgraft vs host diseasemacrophages

Abstract 

The oriental herbal combination allergina has been shown to inhibit allergic inflammation. In the present study, we demonstrate that the oral administration of allergina markedly inhibits the progression of inflammatory diseases, such as graft-versus-host diseases (in the allogeneic bone marrow transplantation and the parent-into-F1 transplantation models), collagen-induced arthritis and sheep red blood cell-induced delayed type hypersensitivity. The immunosuppressive activity of allergina in vivo appears to be associated, at least in part, with the inhibition of tumor necrosis factor-α production. In conclusion, our results suggest that allergina could be useful as a immunosuppressive agent for the treatment of macrophage-related inflammatory disease.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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