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Title 

VDUP1 upregulated by TGF-β1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression

Authors 

Seung Hyun HanJun Ho JeonHyang Ran JuU Hee JungKun Young KimHyang Sook YooY H LeeK S SongH M HwangY S NaYoung YangKee Nyung LeeIn Pyo Choi

Publisher 

Nature Publishing Group

Issue Date 

2003

Citation 

Oncogene, vol. 22, no. 26, pp. 4035-4046

Keywords 

cell cyclePLZFTGF-β1tumorVDUP1protein vdup1transforming growth factor beta1animal cellhuman cell

Abstract 

Vitamin D3 upregulated protein 1 (VDUP1) is a 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) upregulated protein, and it is induced by various stresses. In human tumor tissues, VDUP1 expression was downregulated. Upon stimulation by growth-inhibitory signals such as TGF-β1 and 1,25(OH)2D3, its expression was rapidly upregulated as the cell growth was retarded. The transfection of VDUP1 in tumor cells reduced cell growth. The VDUP1 expression was also increased when the cell-cycle progression was arrested. Transfection of VDUP1 induced cell-cycle arrest at the G0/G1 phase, indicating that VDUP1 possesses a tumor-suppressive activity. In addition, it was found that VDUP1 interacted with promyelocytic leukemia zinc-finger, Fanconi anemia zinc-finger, and histone deacetylase 1, which are known to be transcriptional corepressors. VDUP1 itself suppressed IL-3 receptor and cyclin A2 promoter activity. Taken together, these results suggest that VDUP1 is a novel antitumor gene which forms a transcriptional repressor complex.

ISSN 

0950-9232

Link 

http://dx.doi.org/10.1038/sj.onc.1206610

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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