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Title 

Reprogramming DNA methylation in the preimplantation stage: peeping with Dolly's eyes

Authors 

Yong Kook KangKyung Kwang LeeYong Mahn Han

Publisher 

Elsevier

Issue Date 

2003

Citation 

Current Opinion in Cell Biology, vol. 15, no. 3, pp. 290-295

Keywords 

DNA methyltransferasegenomic DNAhistonecytoplasmdemethylationdevelopmental geneticsDNA methylationDNA replicationgametogenesisgenomics

Abstract 

Oocyte cytoplasmic factors can reprogramme the sperm genome during fertilisation or the somatic cell genome during cloning. Diverse reprogramming machinery acts sequentially and interdependently on the imported genome to drive it to totipotency, but their three-dimensional interactions in the cytoplasm remain unknown. Aberrant epigenetic phenomena in early cloned embryos indicate that parts of the somatic cell genome are unyielding to reprogramming forces, owing to their 'knotty' epigenetic features. This fastidious nature of the donor genome might prevent completion of epigenetic reprogramming. It might also help to explain the chronic developmental defects seen in many cloned embryos.

ISSN 

0955-0674

Link 

http://dx.doi.org/10.1016/S0955-0674(03)00031-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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