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Title 

Dykellic Acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity

Authors 

J H WooJ W ParkS H LeeY H KimI K LeeE GabrielsonSang-Han LeeHo Jae LeeYung Hee KhoT K Kwon

Publisher 

American Association for Cancer Research

Issue Date 

2003

Citation 

Cancer Research, vol. 63, no. 12, pp. 3430-3434

Keywords 

dykellic acidenzyme inhibitorgelatinase Bimmunoglobulin enhancer binding proteinphorbol 13 acetate 12 myristateDNA bindingextracellular matrixprotein expressiongene expression regulation, neoplasticmatrix metalloproteinase 2

Abstract 

Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. These effects of dykellic acid are time- and dose-dependent, and correlate with decreased MMP-9 promoter activity and mRNA expression. Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB.

ISSN 

0008-5472

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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