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Title | 4-hydroxycinnamate lowers plasma and hepatic lipids without changing antioxidant enzyme activities |
Authors | J S Lee; Song Hae Bok; Y B Park; M K Lee; MS Choi |
Publisher | Karger |
Issue Date | 2003 |
Citation | Annals of Nutrition and Metabolism, vol. 47, no. 3, pp. 144-151 |
Keywords | 4-Hydroxycinnamate; antioxidant enzymes; cholesterol metabolism; 3 hydroxy 3 methylglutaryl coenzyme A; antioxidant; enzyme; lipid; enzyme activity; lipid blood level; lipid liver level |
Abstract | Background/Aims: The purpose of this study was to investigate the influence of 4-hydroxycinnamate (4-(OH)-C) supplement on the lipid metabolism and antioxidant system of rats fed a high-cholesterol diet. Methods: Three groups of rats were given a diet containing 1 g cholesterol/kg for 6 weeks. The control group only received a high cholesterol diet, whereas the other two groups received a diet including lovastatin or 4-(OH)-C (0.1 g/100 g). Results: The plasma total cholesterol concentration was significantly lowered by the 4-(OH)-C supplement, whereas the HDL-cholesterol level was higher in this group. The 4-(OH)-C supplement significantly lowered the hepatic cholesterol and triglycerides levels, respectively. Accumulation of hepatic lipid droplet was the highest in control group; however, it was decreased by supplementation of the 4-(OH)-C and the lovastatin. The hepatic HMG-CoA reductase activities were not significantly different between the groups, whereas the ACAT activity was significantly lowered in the lovastatin group. The 4-(OH)-C significantly lowered the hepatic TBARS content. And it did not alter the neutral sterol and total fecal sterol, however, the fecal acidic sterol was higher in the lovastatin and the 4-(OH)-C groups than in the control group. Conclusion: These results indicate that 4-(OH)-C was effective in lowering the plasma cholesterol and hepatic lipids. |
ISSN | 0250-6807 |
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Registered Date |
2019-05-02 |
