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Title 

Torilin from Torilis japonica, as a new inhibitor of testosterone 5α-reductase

Authors 

W S ParkE D SonG W NamS H KimM S NohB G LeeI S JangSe Eun KimJung Joon LeeC H Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2003

Citation 

Planta Medica, vol. 69, no. 5, pp. 459-461

Keywords 

azulenefinasterideguaiazuleneguaiollinoleic acidmethanolplant extractsilica gelsteroid 5alpha reductasesteroid 5alpha reductase inhibitor

Abstract 

The methanolic extract of the fruits of Torilis japonica showed a potent inhibition against 5α-reductase activity in vitro. Bioassay-guided fractionation of the methanol extract of the fruits followed by repeated silica gel chromatography led to the isolation of an active principle and its structure was identified as torilin on the basis of spectroscopic data. Torilin (IC50 = 31.7 ± 4.23 μM) showed a stronger inhibition of 5α-reductase than α-linolenic acid (IC50 = 160.3 ± 24.62 μM) but was weaker than finasteride. (IC50 = 0.38 ± 0.06 μM). Simple guaiane-type compounds, such as (-)-guaiol and guaiazulene showed weak inhibitory effects on the 5α-reductase activity with IC50 values of f 81.6 μM and 100.8 μM, respectively, while azulene was not active. These results suggest that both degrees of unsaturation and the side-chain in the guaiane skeleton are important for the manifestation of 5α-reductase inhibition.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2003-39717

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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