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Title 

Inhibitory effect of TNF-α and IL-8 secretion by pimarane-type diterpenoids from Acanthopanax koreanum

Authors 

X F CaiG ShenN T DatO H KangJ A KimY M LeeJung Joon LeeY H Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2003

Citation 

Chemical & Pharmaceutical Bulletin, vol. 51, no. 5, pp. 605-607

Keywords 

acanthopanax koreanumditerpenoidIL-8inhibitory effectTNF-αacanthopanax koreanum extractinterleukin 8pimaraneprotein secretionacanthopanax

Abstract 

A new pimarane-type diterpene compound, acanthokoreoic acid A together with three known compounds, acanthoic acid, acanthol, and sumogaside were isolated from a CH2Cl2 fraction of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. Acanthoic acid was isolated in high yields and showed potent inhibitory activity on the IL-8 secretion of the TNF-α-stimulated human colon adenocarcinoma cell line HT-29 and on the TNF-α secretion of the trypsin-stimulated human leukemic mast cell line HMC-1.

ISSN 

0009-2363

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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