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Title 

Isolation of an angiotensin converting enzyme inhibitory substance from Chrysanthemum boreale makino

Authors 

J KimS H LeeN SunDong-Ho ChoungWon Gon KimSang Ku LeeK B Song

Publisher 

Wiley-Blackwell

Issue Date 

2003

Citation 

Journal of Food Science, vol. 68, no. 3, pp. 816-819

Keywords 

ACE inhibitorchromatographychrysanthemum boreale makinomass spectrometrychrysanthemum

Abstract 

Thirty plants of the Compositae family were screened for inhibitory activity of angiotensin converting enzyme (ACE) and Chrysanthemum boreale Makino was selected for further investigation since it had the highest inhibitory activity. Crude water extract of the flowers of Chrysanthemum boreale Makino was prepared by steeping in water at 95°C for 2 h, followed by centrifugation at 8000 × g for 30 min. Crude extract was then filtered using YM-3 and YM-1 membranes. An ACE inhibitor was isolated using consecutive chromatographic methods including: gel permeation chromatography, ion exchange chromatography, normal and reverse phase HPLC. The inhibitor was identified to be guanosine by mass spectrometry and NMR studies.

ISSN 

0022-1147

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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