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Title 

Comparative effect of Prunus persica L. BATSCH-water extract and tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride) on concentration of extracellular acetylcholine in the rat hippocampus

Authors 

Y K KimB S KooD J GongY C LeeJung Hun KohC H Kim

Publisher 

Elsevier

Issue Date 

2003

Citation 

Journal of Ethnopharmacology, vol. 87, no. 2, pp. 149-154

Keywords 

acetylcholineacetylcholinesterase inhibitormicrodialysissemen persicae (Prunus persica L. BATSCH)tacrinecholinesterase inhibitorplant extractprunus persica extractunclassified drugwater

Abstract 

Prunus persica L. BATSCH seed-water extract (PPE) has been used in the treatment of the degenerative disorders, such as hypermenorrhea and dysmenorrhea, in Taiwan, China, Japan and Korea. In this study, the effects of oral administration of PPE on the extracellular acetylcholine concentration in the hippocampus of rats were evaluated, and compared to that of tacrine (9-amino-1,2,3,4-tetrahydroacridine hydrochloride), a well-known and centrally acting acetylcholinesterase (AChE) inhibitor, which had been developed for the treatment of Alzheimer's disease. We measured the inhibition of brain AChE. PPE at 2.5g/kg and tacrine at 5mg/kg showed significant effects for more than 6h. At these doses, the maximum increases were observed at about 1.5h after administration of PPE, and at about 2h with tacrine, and were 454 and 412% of the pre-level, respectively. The results suggest that oral administration of PPE and tacrine increases acetylcholine concentration in the synaptic cleft of the hippocampus mostly through AChE inhibition, and that PPE has a potent and long-lasting effect on the central cholinergic system.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/S0378-8741(03)00106-5

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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