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Title 

Silymarin inhibits TNF-α-induced expression of adhesion molecules in human umbilical vein endothelial cells

Authors 

Jong Soon KangSong Kyu ParkKyu-Hwan YangHwan Mook Kim

Publisher 

Elsevier

Issue Date 

2003

Citation 

FEBS Letters, vol. 550, no. 1, pp. 89-93

Keywords 

e-selectinICAM-1NF-κB/RelsilymarinVCAM-1cell adhesion moleculeintercellular cell adhesion moleculevascular cell adhesion molecule 1endothelium cellgene expression regulation

Abstract 

Silymarin is known to have an anti-atherosclerotic activity, but the mechanism responsible for it remains unclear. Here, we demonstrate a possible mechanism involved in the anti-atherosclerotic activity of silymarin. Silymarin inhibited THP-1 cell adhesion to human umbilical vein endothelial cells (HUVECs). Silymarin also suppressed the TNF-α-induced protein and mRNA expression of adhesion molecules, such as VCAM-1, ICAM-1 and E-selectin, in HUVECs. Moreover, silymarin suppressed the TNF-α-induced DNA binding of NF-κB/Rel in HUVECs. Taken together, these results demonstrate that silymarin exerts an anti-atherosclerotic activity, at least in part, by inhibiting the expression of adhesion molecules.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/S0014-5793(03)00827-5

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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