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Title 

Anti-complement activity of constituents from the stem-bark of Juglans mandshurica

Authors 

Byung Sun MinSun Young LeeJung Hee KimJoong Ku LeeTae Jin KimD H KimY H KimHyouk JoungHyeong Kyu LeeN NakamuraH MiyashiroM Hattori

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2003

Citation 

Biological & Pharmaceutical Bulletin, vol. 26, no. 7, pp. 1042-1044

Keywords 

1,2,3,6-tetragalloylglucose1,2,6-trigalloylglucose3,5,7-trihydroxyflavoneanti-complement activityjuglans mandshuricacomplementcomplement inhibitorbarkcomplement inhibitionplant stem

Abstract 

Four known flavonoids and two galloyl glucoses isolated from the stem-bark of Juglans mandshurica (Juglandaceae), namely taxifolin (1), afzelin (2), quercitrin (3), myricitrin (4), 1,2,6-trigalloylglucose (5), and 1,2,3,6-tetragalloylglucose (6), were evaluated for their anti-complement activity against complement system. Afzelin (2) and quercitrin (3) showed inhibitory activity against complement system with 50% inhibitory concentrations (IC50) values of 258 and 440 μM. 1,2,6-Trigalloylglucose (5) and 1,2,3,6-tetragalloylglucose (6) exhibited anti-complement activity with IC 50 values of 136 and 34 μM. In terms of the evaluation of the structure-activity relationship of 3,5,7-trihydroxyflavone, compounds 2, 3, and 4 were hydrolyzed with naringinase to give kaempferol (2a), quercetin (3a), and myricetin (4a) as their aglycones, and these were also tested for their anti-complement activity. of the three aglycones, kaempferol (2a) exhibited weak anti-complement activity with an IC50 value of 730 μM, while quercetin (3a) and myricetin (4a) were inactive in this assay system. Among the compounds tested, 1,2,3,6-tetragalloylglucose (6) showed the most potent anticomplement activity (IC50, 34 μM).

ISSN 

0918-6158

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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