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Title 

Neuroprotective activity of p-Terphenyl leucomentins from the mushroom Paxillus panuoides

Authors 

In Kyoung LeeBong Sik YunJong Pyung KimIn Ja RyooY H KimIck Dong Yoo

Publisher 

Japan Society for Bioscience, Biotechnology and Agrochemistry

Issue Date 

2003

Citation 

Bioscience Biotechnology and Biochemistry, vol. 67, no. 8, pp. 1813-1816

Keywords 

glutamate neurotoxicityiron chelatorleucomentinsmushroompaxillus panuoidespaxillustapinella panuoidesepoxidehydrogen peroxiden methylaspartic acid

Abstract 

The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H 2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.

ISSN 

0916-8451

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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