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Title 

Lignans from Saururus chinensis inhibiting the transcription factor NF-κB

Authors 

Bang Yeon HwangJeong-Hyung LeeJeong Bum NamYoung-Soo HongJung Joon Lee

Publisher 

Elsevier

Issue Date 

2003

Citation 

Phytochemistry, vol. 64, no. 3, pp. 765-771

Keywords 

lignannuclear factor κBsaucerneol Dsaucerneol Esaururaceaesaururus chinensissesquineolignanmanassantin bsaururus chinensis extracttranscription factor

Abstract 

The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-inflammatory activity was studied using HeLa cells transfected with NF-κB reporter construct. All compounds except for (+)-saucernetin inhibited NF-κB dependent reporter gene expression with IC50 values of 2.5-16.9 μM.

ISSN 

0031-9422

Link 

http://dx.doi.org/10.1016/S0031-9422(03)00391-1

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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