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Title 

ent-Kaurane diterpenoids from croton tonkinensis inhibit LPS-induced NF-κB activation and NO production

Authors 

P M GiangH Z JinP T SonJeong-Hyung LeeYoung-Soo HongJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

2003

Citation 

Journal of Natural Products, vol. 66, no. 9, pp. 1217-1220

Keywords 

18 acetoxy 7alpha,14beta dihydroxykaur 16 en 15 one1beta acetoxy 7alpha,14beta dihydroxykaur 16 en 15 one7alpha,14beta dihydroxykaur 16 en 15 onediterpenoidimmunoglobulin enhancer binding proteincarbon nuclear magnetic resonanceconcentration responsecrotoncroton tonkinensisnonhuman

Abstract 

Four ent-kaurane diterpenoids including two known, ent-7α,14β -dihydroxykaur-16-en-15-one (1) and ent-18-acetoxy-7α -hydroxykaur-16-en-5-one (2), and two new, ent-1β-acetoxy-7α,14β -dihydroxykaur-16-en-15-one (3) and ent-18-acetoxy-7α,14β -dihydroxykaur-16-en-15-one (4), were isolated from the leaves of Croton tonkinensis in a search for inhibitors of NF-κB activation and nitric oxide production. These ent-kauranoids inhibited LPS-induced NF-κB activation in murine macrophage RAW264.7 cells at IC50 values between 0.07 and 0.42 μM. Consistently, the ent-kauranoids markedly reduced LPS-induced NO production in a comparable concentration-dependent manner.

ISSN 

0163-3864

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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