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Title 

Expression and localization of the transforming growth factor-β type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats

Authors 

D Y ParkC H LeeM Y SolK S SuhSun Young YoonJae Wha Kim

Publisher 

Korean Academy of Medical Sciences

Issue Date 

2003

Citation 

Journal of Korean Medical Science, vol. 18, no. 4, pp. 510-519

Keywords 

carcinogensliverprecancerous conditionsratsreceptorssignal transductiontransforming growth factor betasmad proteintransforming growth factor beta1animal cell

Abstract 

Little is known about the involvement of Smad-related molecules in the regulation of the Transforming Growth Factor (TGF)-β signaling pathway during hepatocarcinogenesis, particularly with respect to preneoplastic lesions of a rat liver. The aims of this study were to investigate the localizations and temporal expressions of TGF-β Receptor Type 1 (TGR1) and Smads during the promotion stage of chemical hepatocarcinogenesis in rats. We investigated expressions and localizations of TGR1, Smad2, Smad4, and Smad7 by using semi-quantitative RT-PCR and immunohistochemistry in preneoplastic lesions during rat chemical hepatocarcinogenesis induced by Solt and Farber's method. The down-regulation of TGR1, Smad2, and Smad4 was evident during the later steps of the promotion stage of chemical hepatocarcinogenesis. In contrast with other Smads, increased Smad7 expression was evident during the later steps of the promotion stage. Also immunohistochemistry revealed that the main site of TGR1, Smad2, Smad4, and Smad7 expression was mainly in hepatocytes of the preneoplastic lesions of a rat liver. Dysregulation of the downstream effectors of TGF-β such as TGR1, Smad2, Smad4 and, Smad7 might contribute to the progression of preneoplastic lesions during chemical hepatocarcinogenesis in a rat.

ISSN 

1011-8934

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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