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Title 

Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa

Authors 

Seung Ho LeeMi Young LeeHyun Mi KangDong Cho HanKwang Hee SonD C YangN D SungChang Woo LeeHwan Mook KimByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2003

Citation 

Bioorganic & Medicinal Chemistry, vol. 11, no. 21, pp. 4545-4549

Keywords 

antineoplastic agentprotein farnesyltransferase inhibitorantineoplastic activitytumor cellalkyl and aryl transferasesantineoplastic agentscell line, tumorenzyme inhibitorsfarnesyltranstransferasetumor suppressor proteins

Abstract 

Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2003.08.008

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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