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Title 

Expression of endoplasmic reticulum chaperone ERp29 in the injured spinal cord

Authors 

S J ParkH M HwangY H LeeK H YouKee Sun ShinO Y Kwon

Issue Date 

2003

Citation 

Korean Journal of Biological Sciences, vol. 7, no. 0, pp. 265-269

Keywords 

ERp29endoplasmic reticulumchaperonespinal cord injury

Abstract 

Regulation of endoplasmic reticulum (ER) chaperone, ERp29, in traumatized rat spinal cord was investigated. Compared to the control, ERp29 expression was down-regulated at the lesion site 1 d after spinal cord injury. However, ERp29 expression gradually increased from 3 d after the injury and peaked remarkably after 7 d. Two ER chaperones (GRP94 and BiP) showed constantly strong expression levels 1 d after spinal cord injury while the expression levels of the other two (calnexin and PDI) were unchanged. In the case of ERp72, its expression level was increased 1 d after the injury and gradually decreased thereafter. This study suggests that ERp29 expression in the spinal cord after traumatic injury might be associated with the posttraumatic neural survival, playing a role as a molecular chaperone.

ISSN 

1226-5071

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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