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Title 

Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki

Authors 

Mun Chual RhoMi Yeon ChungHye Young SongOh Eok KwonSeung Woong LeeJin Ah BaekK H JeuneKoanhoi KimHyun Sun LeeYoung Kook Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2003

Citation 

Archives of Pharmacal Research, vol. 26, no. 9, pp. 716-718

Keywords 

acyl-CoAcholesterol acyltransferasediospyros kakipheophorbide A-methyl ester

Abstract 

In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 μg/mL.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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