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Title 

Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines

Authors 

M H KaplanH C ChangS CooperYong Hee LeeH E Broxmeyer

Publisher 

Mary Ann Liebert

Issue Date 

2003

Citation 

Journal of Hematotherapy and Stem Cell Research, vol. 12, no. 4, pp. 401-408

Keywords 

granulocyte macrophage colony stimulating factorgrowth factorSTAT4 proteinSTAT6 proteinsteel factorcell subpopulationhelper cellhematopoietic stem cellTh1 cellbone marrow cells

Abstract 

Hematopoietic progenitor cell (HPC) homeostasis is critical in maintaining innate immunity and healing processes. Recently, we demonstrated that Th1 cells regulate HPC homeostasis, partly based on altered homeostasis in Stat4- and Stat6-deficient mice. To explore changes in HPC responsiveness in altered T helper cell environments, we directly examined growth factor-stimulated colony formation and chemokine-induced myelosuppression of HPC in Stat4- and Stat6-deficient bone marrow cells. Stat6-deficient cells have increased responses to the synergy between granulocyte-macrophage colony-stimulating factor (GM-CSF) and steel factor (SLF), compared to wild-type and Stat4-deficient cells. Increased responses are eliminated by in vivo depletion of CD4 cells. Whereas Stat6-deficient bone marrow cells respond to chemokine-mediated myelosuppression, Stat4-deficient bone marrow cells are refractory to the suppressive effects of chemokines. Thus, T helper cell development affects HPC homeostasis through several mechanisms, including the sensitivity to growth factor stimulation and chemokine suppression of HPC colony formation. Since Stat4 and Stat6 regulate opposing programs of T helper differentiation, there are distinct requirements for Stat4 and Stat6 in regulation of growth factor and chemokine responses of HPC.

ISSN 

1547-3287

Link 

http://dx.doi.org/10.1089/152581603322286033

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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