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Title 

The absolute configuration of prunioside A from Spiraea prunifolia and biological activities of related compounds

Authors 

Hyun Cheol OhH S ShinG S OhH O PaeK Y ChaiH T ChungH S Lee

Publisher 

Elsevier

Issue Date 

2003

Citation 

Phytochemistry, vol. 64, no. 6, pp. 1113-1118

Keywords 

inhibitory effects on nitric oxide (NO) productionmosher's methodprunioside Arosaceaespiraea prunifoliaplant extractprunioside aunclassified druganimal cellcarbon nuclear magnetic resonance

Abstract 

The stereochemistry of prunioside A isolated from Spiraea prunifolia was determined by chemical transformations and NMR spectral data analysis, The configurations at C-5 and C-6 were determined to be 5S and 6R by application of the modified Mosher's method, CD analysis, and 13C NMR spectroscopic data analysis of an acetonide derivative. Other compounds related to prunioside A have inhibitory effects on the synthesis of nitric oxide in LPS-stimulated macrophage-like RAW 264.7 cells.

ISSN 

0031-9422

Link 

http://dx.doi.org/10.1016/S0031-9422(03)00499-0

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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