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Title 

Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola

Authors 

H J JungHyang Burm LeeC H LimChang-Jin KimH J Kwon

Publisher 

Elsevier

Issue Date 

2003

Citation 

Bioorganic & Medicinal Chemistry, vol. 11, no. 22, pp. 4743-4747

Keywords 

angiogenesis inhibitorcochlioquinone A1unclassified drugangiogenesisanimal cellaortabipolaris zeicolacancer cell culturecattlenonhuman

Abstract 

Cochlioquinone A1 (CoA1) was newly isolated from the culture extract of Bipolaris zeicola as a potent anti-angiogenic agent. CoA1 inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced tube formation and invasion at the concentration (1 μg/mL) without cytotoxicity. Notably, CoA1 exhibited more potent inhibition activity for the growth of BAECs than that of normal and cancer cell lines investigated in this study. These results demonstrate that CoA1 is a new anti-angiogenic agent and can be developed as a new therapeutic agent for angiogenesis-related diseases.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/S0968-0896(03)00523-6

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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