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Title 

Fine mapping of the circling(cir) gene on the distal portion of mouse chromosome 9

Authors 

K I ChoJeong Woong LeeK S KimE J LeeJ G SuhH J LeeH T KimS H HongW H ChungKyu Tae ChangByung Hwa HyunY S OhZ Y Ryoo

Publisher 

American Association for Laboratory Animal Science

Issue Date 

2003

Citation 

Comparative Medicine, vol. 53, no. 6, pp. 642-648

Keywords 

chromosome 9cir genecircling behaviorgenegene locationgene mappinggenetic linkagemousemouse strainyeast artificial chromosome

Abstract 

Circling mice manifest profound deafness, head-tossing, and bi-directional circling behavior, which they inherit in autosomal recessive manner. Histologic examination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. A genetic linkage map was constructed for an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mit116/D9Mit15 and D9Mit38 on mouse chromosome (Chr) 9. Estimated distances between cir and D9Mit116, and between cir and D9Mit38 were 0.70 ± 0.40 and 0.23 ± 0.23 cM, respectively. Order of the markers was defined as follows: centromere - D9Mit182 - D9Mit51/D9Mit79/D9Mit310 -D9Mit212/D9Mit184 - D9Mit116/D9Mit15 - cir - D9Mit38 - D9Mit20 - D9Mit243 - D9Mit16 - D9Mit55/D9Mit125 - D9Mit281. On the basis of genetic mapping, we constructed a yeast artificial chromosome (YAC) contig across the cir region. The cir gene is located between the lactotransferrin (ltf) and microtubule-associated protein (map4) genes. The distal portion of mouse Chr 9 encompassing the cir region is homologous with human chromosome 3p21, which contains the Deafness, form B: Autosomal Recessive Deafness (DFNB6) locus. Therefore, the circling mouse is a potential animal model for DFNB6 deafness in humans.

ISSN 

1532-0820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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