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Title 

Inhibitory effect of kaurane type diterpenoids from Acanthopanax koreanum on TNF-α secretion from trypsin-stimulated HMC-1 cells

Authors 

X F CaiG ShenN T DatO H KangYoung Mi LeeJung Joon LeeY H Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2003

Citation 

Archives of Pharmacal Research, vol. 26, no. 9, pp. 731-734

Keywords 

acanthopanax koreanuminhibitory effectkaurane type diterpenoidTNF-α secretion

Abstract 

Five known kaurane type diterpenoids, 16α H,17-isovaleryloxy- ent-kauran-19-oic acid (1), 16α-hydroxy-17-isovaleryloxy- ent-kauran-19-oic acid (2), paniculoside-IV (3), 16α-hydroxy- ent-kauran-19-oic acid (4), and ent-kaur-16-en-19-oic acid (5) were isolated from the root of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. The structures of these compounds were established from physicochemical and spectral data. Among the isolated compounds 16α H,17-isovaleryloxy- ent-kauran-19-oic acid (1) showed potent inhibitory activity (IC50 value, 16.2 uM) on TNF-α secretion from HMC-1, a trypsin-stimulated human leukemic mast cell line.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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