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Title 

Two cinnamate derivatives produce similar alteration in mRNA expression and activity of antioxidant enzymes in rats

Authors 

M K LeeE M ParkSong Hae BokU J JungJ Y KimY B ParkT L HuhO S KwonM S Choi

Publisher 

Wiley-Blackwell

Issue Date 

2003

Citation 

Journal of Biochemical and Molecular Toxicology, vol. 17, no. 5, pp. 255-262

Keywords 

3-(4-Hydroxyphenyl)-propionic acid4-HydroxycinnamateAntioxidant enzymesErythrocytemRNA expressionantioxidantcinnamic acid derivativeliver enzymephenol derivativeantioxidant activity

Abstract 

Cinnamate is a widespread secondary metabolite of phenolic compound synthesized by plants for defensive purposes. The current study was designed to investigate the effect of two structurally related cinnamate derivatives, 4-hydroxycinnamate and 3-(4-hydroxyphenyl)propionic acid (HPP), on the mRNA expression and activity of antioxidant enzymes in high-cholesterol-fed rats. Male rats were fed a 1 g/100 g high-cholesterol diet with supplements of either 4-hydroxycinnamate or HPP (0.135 mmol/100 g diet) for 6 weeks. The plasma paraoxonase activity was found to be higher in the cinnamate-derivative-supplemented groups than in the control group. The erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities, plus glutathione (GSH) level, were all significantly higher in the 4-hydroxycinnamate- and HPP-supplemented groups than in the control group. However, both 4-hydroxycinnamate and HPP supplementation significantly lowered the hepatic activities and mRNA expression of CAT and glutathione peroxidase (GSH-Px) compared to the control group. The hepatic mRNA expression and activity of SOD did not differ between the groups. The hepatic thiobarbituric acid reactive substances (TBARS) level was significantly lowered by the 4-hydroxycinnamate and HPP supplementation. Accordingly, these results indicate that supplementation by 4-hydroxycinnamate and HPP would seem to enhance the antioxidative defense of erythrocyte. Both HPP and 4-hydroxycinnamate would appear to be beneficial in improving the function of antioxidative enzymes on a molecular level in high-cholesterol-fed rats.

ISSN 

1095-6670

Link 

http://dx.doi.org/10.1002/jbt.10087

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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