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Title 

Inhibitory effects of manassantin A and B isolated from the roots of Saururus chinensis on PMA-induced ICAM-1 expression

Authors 

Mun Chual RhoOh Eok KwonKoanhoi KimSeung Woong LeeMi Yeon ChungY H KimM HayashiHyun Sun LeeYoung Kook Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2003

Citation 

Planta Medica, vol. 69, no. 12, pp. 1147-1149

Keywords 

intercellular adhesion molecule 1lymphocyte function associated antigen 1manassantin Amanassantin Bmethanolphorbol 13 acetate 12 myristateplant extractsaururus chinensis extractunclassified drugcell adhesion

Abstract 

Cell adhesion inhibitors were isolated from the methanol extract of Saururus chinensis roots by bioactivity-guided fractionation. The active compounds were identified as manassantin A (1) and B (2), dineolignan compounds. Compounds 1 and 2 inhibited PMA-induced ICAM-1/LFA-1-mediated homotypic aggregation of the HL-60 cells without cytotoxicity with MIC values of 1.0 and 5.5 nM, respectively. Even though 1 and 2 did not affect the adhesion of ICAM-1 to LFA-1, these compounds inhibited PMA-induced ICAM-1 expression in HL-60 cells in a dose-dependent fashion. These results suggest that 1 and 2 inhibit cell aggregation through down-regulation of ICAM-1 expression.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2003-818007

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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