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Title 

Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii(I): taxonomy, fermentation, isolation and biological properties

Authors 

Jong Pyung KimByoung Kwon KimBong Sik YunIn Ja RyooChoong Hwan LeeIn Kyung LeeWon Gon KimSangku LeeY R PyunIck Dong Yoo

Publisher 

Nature Publishing Group

Issue Date 

2003

Citation 

Journal of Antibiotics, vol. 56, no. 12, pp. 993-999

Keywords 

1,1 diphenyl 2 picrylhydrazylalpha tocopherolbutylated hydroxyanisoledermatological agentisocyanic acid derivativemelanocin Amelanocin Bmelanocin Cmonophenol monooxygenasescavenger

Abstract 

New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nm and MIC value of 0.9 μM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.

ISSN 

0021-8820

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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