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Title 

Saucernetin-7 and saucernetin-8 isolated from Saururus chinensis inhibit the LPS-induced production of nitric oxide and prostaglandin E-2 in macrophage RAW264.7 cells

Authors 

H J ParkR G KimB R SeoJ H HaByung Tae AhnSong Hae BokY S LeeH J KimK T Lee

Publisher 

Georg Thieme Verlag

Issue Date 

2003

Citation 

Planta Medica, vol. 69, no. 10, pp. 947-950

Keywords 

inducible nitric oxide synthasenitric oxidesaucernetin 7saucernetin 8enzyme inhibitionsaururus chinensisnitric oxide synthasenitric oxide synthase type II

Abstract 

In the present study, we demonstrate that saucernetin-8 (1) and saucernetin-7 (2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production in RAW 264.7 cells. Both compounds 1 and 2, known as dineolignans, also suppressed the expression of iNOS and COX-2 protein in a dose-dependent manner. Thus, this study suggests that compounds 1 and 2-mediated inhibition of iNOS and COX-2 expression may be one of the mechanisms responsible for the anti-inflammatory effects of the underground parts of Saururus chinensis.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2003-45106

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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