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Title 

Isolation and anticomplement activity of compounds from Dendropanax morbifera

Authors 

Bo Young ParkByung Sun MinSei Ryang OhJung Hee KimTae Jin KimD H KimK H BaeHyeong Kyu Lee

Publisher 

Elsevier

Issue Date 

2004

Citation 

Journal of Ethnopharmacology, vol. 90, no. 2, pp. 403-408

Keywords 

(9Z,16S)-16-Hydroxy- 9,17-octadecadiene-12,14-diynoic acidanticomplement activitydendropanax morbifera Leveillepolyacetylenedendropanax morbifera

Abstract 

Dendropanax morbifera Leveille (Araliaceae) is used in Korea for a variety of disease, such as migraine headache and dysmenorrheal. A new polyacetylene (1) and six known compounds (2-7) were isolated from the leaves of this plant by conventional chromatographic techniques. The structure of the new polyacetylene (1) was determined as (9Z,16S)-16-hydroxy-9,17-octadecadiene-12,14-diynoic acid by spectroscopic means including 2D NMR, which comprised the determination of a chiral by modified Mosher's ester method. Compounds 1-7 were investigated in vitro for their anticomplement activity against the classical pathway of the complement system. of these, compound 1 showed significant anticomplement activity with 50% inhibitory concentration (IC50) value of 56.98μM, whereas compounds 2-7 were inactive.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2003.11.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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