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Title | Phenotype of peroxisome proliferator-activated receptor-α(PPARα) deficient mice on mixed background fed high fat diet |
Authors | B H Kim; Young Suk Won; E Y Kim; M J Yoon; K T Nam; Goo Taeg Oh; D Y Kim |
Publisher | The Korean Society of Veterinary Science |
Issue Date | 2003 |
Citation | Journal of Veterinary Science, vol. 4, no. 3, pp. 239-244 |
Keywords | C57BL mouse; fat intake; mouse; mouse mutant; dietary fats; mice; mice, inbred C57BL; mice, knockout |
Abstract | Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation. |
ISSN | 1229-845X |
Appears in Collections | |
Registered Date |
2017-04-19 |
