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Title 

Phenotype of peroxisome proliferator-activated receptor-α(PPARα) deficient mice on mixed background fed high fat diet

Authors 

B H KimYoung Suk WonE Y KimM J YoonK T NamGoo Taeg OhD Y Kim

Publisher 

The Korean Society of Veterinary Science

Issue Date 

2003

Citation 

Journal of Veterinary Science, vol. 4, no. 3, pp. 239-244

Keywords 

C57BL mousefat intakemousemouse mutantdietary fatsmicemice, inbred C57BLmice, knockout

Abstract 

Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation.

ISSN 

1229-845X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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