상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer

Authors 

Q L LiH R KimW J KimJ K ChoiY H LeeHwan Mook KimL S LiH G KimJ ChangY ItoK Y LeeS C Bae

Publisher 

Elsevier

Issue Date 

2004

Citation 

Biochemical and Biophysical Research Communications, vol. 314, no. 1, pp. 223-228

Keywords 

lung cancermethylationRUNX3TGF-βtranscriptiontranscription factor RUNX3cancer cell cultureCpG islandgene expressiongene silencing

Abstract 

RUNX family transcription factors are integral components of TGF-β signaling pathways and have been implicated in cell cycle regulation, differentiation, apoptosis, and malignant transformation. It was noted previously that allele loss and loss of expression of RUNX3 are causally involved in gastric carcinogenesis. Our results demonstrate that RUNX3 is inactivated by aberrant DNA methylation in approximately 19% of lung cancer cell lines and 24% of primary lung cancer specimens. RUNX3 methylation is tumor-specific, since it is not observed in surrounding normal lung tissues. Our results suggest that loss of RUNX3 expression by DNA hypermethylation is frequently associated with the evolution of lung cancer.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2003.12.079

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)