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Title 

Complestatin prevents apoptotic cell death: inhibition of a mitochondrial caspase pathway through AKT/PKB activation

Authors 

E C KimBong Sik YunIn Ja RyooJeong Ki MinM H WonK S LeeY M KimIck Dong YooY G Kwon

Publisher 

Elsevier

Issue Date 

2004

Citation 

Biochemical and Biophysical Research Communications, vol. 313, no. 1, pp. 193-204

Keywords 

AKT/PKBapoptosiscaspasescomplestatinTRAILcaspase 3caspase 8death receptor 5hexapeptideprotein BAD

Abstract 

Complestatin, a bicyclo hexapeptide from Streptomyces, was isolated as a possible regulator of neuronal cell death. In this study, we report an anti-apoptotic activity of complestatin and its underlying molecular mechanism. Complestatin blocked TRAIL (TNF-related apoptosis-inducing ligand)-induced apoptosis and activation of caspase-3 and -8 at micromolar concentration levels without inhibiting the catalytic activities of these caspases. Complestatin potently induced a rapid and sustained AKT/PKB activation and Bad phosphorylation, resulting in inhibition of mitochondrial cytochrome c release. These anti-apoptotic activities of complestatin were significantly abrogated in cells expressing dominant negative AKT/PKB. Taken together, our results suggest that complestatin prevents apoptotic cell death via AKT/PKB-dependent inhibition of the mitochondrial apoptosis signal pathway. The novel property of complestatin may be valuable for developing new pharmaceutical means that will control unwanted cell death.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2003.11.104

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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