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Title 

Screening of the inhibitory activity of medicinal plants against protein tyrosine phosphatase 1B

 

생약의 protein tyrosine phosphatase 1B(PTP1B) 저해활성 검색

Authors 

Jung Hyun HongMyung Sun LeeEun Young BaeY H KimHyuncheol OhWon Keun OhBo Yeon KimJong Seog Ahn

Publisher 

Korean Society of Pharmacognosy

Issue Date 

2004

Citation 

Korean Journal of Pharmacognosy, vol. 35, no. 1, pp. 16-21

Keywords 

insulinmedicinal plantsPTP1Btype II diabetesprotein tyrosine phosphatase 1Bprotein tyrosine phosphatase 1B inhibitordrug screeninghigher plant

Abstract 

Protein tyrosine phosphatase 1B(PTP1B) is thought to be a negative regulator in insulin signal-transduction pathway. Insulin-resistance by the activation of PTP1B is a hallmark of both type 2 diabetes and obesity. Thus, the compounds inhibiting PTP1B can improve insulin resistance and can be effective in treating type 2 diabetes and obesity. The methanol extracts of 160 herbal medicines were screened for the inhibitory activity against PTP1B. Among the tested extracts, methanol extracts of Amsonia elliptica, Areca catechu, Benincasa hispida, Morus alba, Salvia miltiorrhiza, Siegesbeckia orientalis, and Trichosanthes kirilowii showed relatively strong inhibitory activity against PTP1B.

ISSN 

0253-3073

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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