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Title 

Wogonin inhibits excitotoxic and oxidative neuronal damage in primary cultured rat cortical cells

Authors 

J S ChoHyeong Kyu Lee

Publisher 

Elsevier

Issue Date 

2004

Citation 

European Journal of Pharmacology, vol. 485, no. 1, pp. 105-110

Keywords 

antioxidantcortical neuronexcitotoxicityneuroprotectionoxidative damagewogoninanimal cellbrain cellnerve cell culturenerve cell lesion

Abstract 

The present study evaluated effects of wogonin (5,7-dihydroxy-8- methoxyflavone) on excitotoxic and oxidative stress-induced neuronal damage in primary cultured rat cortical cells. Wogonin was shown to inhibit the excitotoxicity induced by glutamate or N-methyl-D-aspartic acid, whereas it showed no effects on the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid- or kainate-induced toxicity. In addition, wogonin inhibited the oxidative neuronal damage induced by H2O2, xanthine/xanthine oxidase, and by a glutathione depleting agent D,L-buthionine [S,R]-sulfoximine. Furthermore, wogonin dramatically inhibited lipid peroxidation initiated by Fe2+ and L-ascorbic acid in rat brain homogenates. It also exhibited 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity. Taken together, these results demonstrate that wogonin exhibits neuroprotective actions in cultured cortical cells by inhibiting excitotoxicity and various types of oxidative stress-induced damage, and that its antioxidant actions with radical scavenging activity may contribute, at least in part, to the neuroprotective effects.

ISSN 

0014-2999

Link 

http://dx.doi.org/10.1016/j.ejphar.2003.11.064

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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