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Title 

Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor γ through protein-protein interaction

Authors 

Y H ChoiH I KimJ K SeongDae Yeul YuH S ChoM O LeeJ M LeeY H AhnS J KimJ H Park

Publisher 

Elsevier

Issue Date 

2004

Citation 

FEBS Letters, vol. 557, no. 1, pp. 73-80

Keywords 

hepatitis B virus X proteinperoxisome proliferator-activated receptor γprotein-protein interactiontransactivationperoxisome proliferator activated receptor gammavirus proteinx proteinanimal experimentbinding sitegrowth inhibition

Abstract 

Ligand activation of peroxisome proliferator-activated receptor γ (PPARγ) has been reported to induce growth inhibition and apoptosis in various cancers including hepatocellular carcinoma (HCC). However, the effect of hepatitis B virus X protein (HBx) on PPARγ activation has not been characterized in hepatitis B virus (HBV)-associated HCC. Herein, we demonstrated that HBx counteracted growth inhibition caused by PPARγ ligand in HBx-associated HCC cells. We found that HBx bound to DNA binding domain of PPARγ and HBx/PPARγ interaction blocked nuclear localization and binding to recognition site of PPARγ. HBx significantly suppressed a PPARγ-mediated transactivation. These results suggest that HBx modulates PPARγ function through protein-protein interaction.

ISSN 

0014-5793

Link 

http://dx.doi.org/10.1016/S0014-5793(03)01449-2

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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