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Title 

Effect of D-lactate on the physiological activity of the ArcB sensor kinase in Escherichia coli

Authors 

C RodriguezOh Suk KwonD Georgellis

Publisher 

American Society for Microbiology

Issue Date 

2004

Citation 

Journal of Bacteriology, vol. 186, no. 7, pp. 2085-2090

Keywords 

ArcB sensor kinaselactic acidprotein kinaseunclassified drugenzyme activityescherichia colisignal transductionculture mediaescherichia coli proteinsprotein kinases

Abstract 

The Arc two-component system, comprising the ArcB sensor kinase and the ArcA response regulator, modulates the expression of numerous genes in response to the respiratory growth conditions. Under anoxic growth conditions ArcB autophosphorylates and transphosphorylates ArcA, which in turn represses or activates its target operons. The anaerobic metabolite D-lactate has been shown to stimulate the in vitro autophosphorylating activity of ArcB. In this study, the in vivo effect of D-lactate on the kinase activity of ArcB was assessed. The results demonstrate that D-lactate does not act as a direct signal for activation of ArcB, as previously proposed, but acts as a physiologically significant effector that amplifies ArcB kinase activity.

ISSN 

0021-9193

Link 

http://dx.doi.org/10.1128/JB.186.7.2085-2090.2004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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