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Title 

New polyacetylenes, DGAT inhibitors from the roots of Panax ginseng

Authors 

Seung Woong LeeK H KimMun Chual RhoMi Yeon ChungY H KimSangku LeeHyun Sun LeeYoung Kook Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2004

Citation 

Planta Medica, vol. 70, no. 3, pp. 197-200

Keywords 

araliaceaediacylglycerol acyltransferase (DGAT)panax ginsengpolyacetylenesstructure elucidationginseng extractginsengplant rootenzyme Inhibitorsinhibitory concentration 50

Abstract 

The petroleum ether extract of Panax ginseng showed a significant inhibition of the diacylglycerol acyltransferase (DGAT) enzyme from rat liver microsomes. Bioactivity-guided fractionation led to the isolation of two new polyacetylenic compounds, (9R,10S)-epoxyheptadecan-4,6-diyn-3-one (1) and 1-methoxy-(9R,10S)-epoxyheptadecan-4,6-diyn-3-one (2). Their chemical structures were elucidated on the basis of spectroscopic evidence and asymmetric synthesis. IC50 values of 9 μg/mL (1) and 32 μg/ml (2) were obtained.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2004-815534

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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