상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

In vitro inhibition of diacylglycerol acyltransferase by prenylflavonoids from Sophora flavescens

Authors 

Mi Yeon ChungMun Chual RhoJeong Suk KoS Y RyuK H JeuneK H KimHyun Sun LeeYoung Kook Kim

Publisher 

Georg Thieme Verlag

Issue Date 

2004

Citation 

Planta Medica, vol. 70, no. 3, pp. 258-260

Keywords 

diacylglycerol acyltransferasehesperetinkuraridinkurarinolkurarinonenaringeninquercetinsophora flavescens extractenzyme inhibitionin vitro study

Abstract 

Four prenylflavonoids, kurarinone (1), a chalcone of 1, kuraridin (2), kurarinol (3), kushenol H (4) and kushenol K (5) isolated from the roots of Sophora flavescens were investigated for their inhibitory effects on diacylglycerol acyltransferase (DGAT). The flavonoids inhibited DGAT activity in a dose-dependent manner with IC50 values of 10.9 μM (1), 9.8 μM (2), 8.6 μM (3), 142.0 μM (4) and 250 μM (5). The prenylflavonoids without C3-OH (1,2,3) showed stronger inhibition than those with C3-OH (4,5). On the other hand, flavonoids without side chains (hesperetin, naringenin, quercetin and kaempferol) did not inhibit the enzyme activity at a final concentration of 800 μM. These data suggest that the lavandulyl side chain and the position of the hydroxy group are important for high DGAT inhibitory activity. Compound 1 also inhibited de novo synthesis of triacylglycerol (TG) in Raji cells.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-2004-815545

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)