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Title 

Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors

Authors 

Tae Sook JeongKyung Soon KimSo Jin AnKyung Hyun ChoSangku LeeWoo Song Lee

Publisher 

Elsevier

Issue Date 

2004

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 14, no. 11, pp. 2715-2717

Keywords 

ACAT inhibitorcholesterol acyltransferasecholesterol acyltransferase inhibitornonhumanenzyme inhibitorshumansinhibitory concentration 50sterol o-acyltransferase

Abstract 

A series of pyrazoline derivatives were prepared for evaluating their acyl-CoA:cholesterol acyltransferase activities. 3-(3,5-Di-tert-butyl-4- hydroxyphenyl)-5-(multi-substituted 4-hydroxyphenyl)-2-pyrazolines 4a-i were shown in vitro inhibitory activity on hACAT-1 and -2.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2004.03.079

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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